Jansen et al. (2004) investigated the possible cytotoxic effects, biocompatibility and degradation of a hyaluronan-based conduit for peripheral nerve repair. T he results show that a hyaluronan-based conduit is not cytotoxic and shows good biocompatibility. Hyaluronan is highly non-antigenic and nonimmunogenic, owing to its high structural homology across species, and poor interaction with blood components (Amarnath et al., 2006